Plenary Lectures
Anadolu Auditorium
5.7.2025
17:00 – 18:00h
FEBS Sir Hans Krebs Lecture – Opening Plenary Lecture
Chairs: Miguel A. de la Rosa (ES) Tomris Özben (TR)
G Protein-coupled Peptide Receptors: Structure, Function and Innovative Therapeutic Concepts
Beck-Sickinger, Annette (Germany)
17:00h - 18:00h
Regulation of Subcellular Architecture and Organelle Function in Health and Disease
Hotamisligil, Gokhan (United States of America)
18:30h - 19:30h
Symposia
Anadolu Auditorium
6.7.2025
09:00 – 11:00h
Structural biology: from complexes to membrane-less organelles
Chairs: Umut Sahin (TR) Edward A. Lemke (DE)
Molecular mechanisms of DNA repair in bacteria
Nowotny, Marcin (Poland)
09:00h - 09:25h
Symposia
Anadolu Auditorium
6.7.2025
09:00 – 11:00h
Structural biology: from complexes to membrane-less organelles
Chairs: Umut Sahin (TR) Edward A. Lemke (DE)
Decoding Molecular Plasticity in the Dark Proteome
Lemke, Edward (Germany)
09:25h - 09:50h
Symposia
Anadolu Auditorium
6.7.2025
09:00 – 11:00h
Structural biology: from complexes to membrane-less organelles
Chairs: Umut Sahin (TR) Edward A. Lemke (DE)
Centromeres, kinetochores, and their specification
Musacchio, Andrea (Germany)
09:50h - 10:15h
Symposia
Anadolu Auditorium
6.7.2025
09:00 – 11:00h
Structural biology: from complexes to membrane-less organelles
Chairs: Umut Sahin (TR) Edward A. Lemke (DE)
Unraveling the structural impact of DNA on RARα/RXR transcriptional regulation
Tambones, Izabella (France)
10:15h - 10:30h
Symposia
Anadolu Auditorium
6.7.2025
09:00 – 11:00h
Structural biology: from complexes to membrane-less organelles
Chairs: Umut Sahin (TR) Edward A. Lemke (DE)
DnaB and DciA: mechanisms of helicase loading and translocation on ssDNA during the DNA replication initiation in human pathogenic bacteria
Mazzoletti, Daniele (Italy)
10:30h - 10:45h
Symposia
Anadolu Auditorium
6.7.2025
09:00 – 11:00h
Structural biology: from complexes to membrane-less organelles
Chairs: Umut Sahin (TR) Edward A. Lemke (DE)
The unexpected structure and function of the BAM complex in Bacteroidetes
Madej, Mariusz (Poland)
10:45h - 10:48h
Symposia
Hall 1
6.7.2025
09:00 – 11:00h
FEBS & Cell Death Research Society Joint Session – Cell stress, cell senescence, and cell death decisions
Chairs: H. Seda Vatansever (TR) Peter Vandenabeele (BE)
Senescence and targeted senolysis
Gorgoulis, Vasilis (Greece)
09:00h - 09:25h
Symposia
Hall 1
6.7.2025
09:00 – 11:00h
FEBS & Cell Death Research Society Joint Session – Cell stress, cell senescence, and cell death decisions
Chairs: H. Seda Vatansever (TR) Peter Vandenabeele (BE)
Interaction between ferroptotic dying cancer cells and the immune system
Vandenabeele, Peter (Belgium)
09:25h - 09:50h
Symposia
Hall 1
6.7.2025
09:00 – 11:00h
FEBS & Cell Death Research Society Joint Session – Cell stress, cell senescence, and cell death decisions
Chairs: H. Seda Vatansever (TR) Peter Vandenabeele (BE)
Enhancing immune-mediated killing of senescent cells
Gil, Jesus (United Kingdom)
09:50h - 10:15h
Symposia
Hall 1
6.7.2025
09:00 – 11:00h
FEBS & Cell Death Research Society Joint Session – Cell stress, cell senescence, and cell death decisions
Chairs: H. Seda Vatansever (TR) Peter Vandenabeele (BE)
Lysosome-mitochondria crosstalk in nutrient-restricted cells remodel cell signalling for survival
Hüsnügil, Hepşen Hazal (Türkiye)
10:15h - 10:30h
Symposia
Hall 1
6.7.2025
09:00 – 11:00h
FEBS & Cell Death Research Society Joint Session – Cell stress, cell senescence, and cell death decisions
Chairs: H. Seda Vatansever (TR) Peter Vandenabeele (BE)
Skin fibroblasts’ response to UVB irradiation: apoptosis, premature senescence or resistance?
Kletsas, Dimitris (Greece)
10:30h - 10:45h
Symposia
Hall 1
6.7.2025
09:00 – 11:00h
FEBS & Cell Death Research Society Joint Session – Cell stress, cell senescence, and cell death decisions
Chairs: H. Seda Vatansever (TR) Peter Vandenabeele (BE)
Determination of the effect of EF24 on the cell death response induced by eribulin mesylate in A549 lung cancer cells
Soylemez, Sibel (Türkiye)
10:45h - 10:48h
Metabolic rewiring driving metastasis formation
Fendt, Sarah-Maria (Belgium)
09:00h - 09:25h
A KEAP1-dependent trade-off between migration and ferroptosis limits melanoma hematogenous dissemination
Dupont, Sirio (Italy)
09:25h - 09:50h
Fueling the battle: Metabolic insights into cancer progression and anti-tumor immunity’
Ricci, Jean-Ehrland (France)
09:50h - 10:15h
Hypoxia and HIF2-α related α-ketoglutarate accumulation as a therapeutic target for reverting macrophage metabolic reprogramming and immune evasion in MASH-related HCC.
Foglia, Beatrice (Italy)
10:15h - 10:30h
Cytosolic EZH2-IMPDH2 complex regulates melanoma progression and metastasis via GTP
Kuser Abali, Gamze (Australia)
10:30h - 10:45h
Investigation of Stage-Specific Exosomal Content in Small Cell Lung Cancer by Multi-Omics Approach and Investigation of Possible Effects in Organotropic In Vivo SCID Mouse Model
inci, Kubilay (Türkiye)
10:45h - 10:48h
Epigenetic regulation by histone acetylation in health and disease
Akhtar, Asifa (Germany)
11:30h - 12:30h
Biomolecular condensates and their implications for cell physiology and disease
Hyman, Anthony (Germany)
14:30h - 15:30h
Antibiotic Efficacy - Why Context Matters
SANTUCCI, Pierre (France)
16:00h - 16:30h
Dynamic RNA biology at the single-molecule level: Watching how interconnected processes work in real-time
Duss, Olivier (Germany)
16:30h - 17:00h
Understanding breast tumor formation and treatment response in context of the host
Scheele, Colinda (Belgium)
17:00h - 17:30h
The Molecular Architecture of a 2MDa Plastid-Encoded RNA Polymerase in a Unicellular Photosynthetic Eukaryote
Ramundo, Silvia (Austria)
17:30h - 18:00h
Deciphering the epigenetic code in autophagy and cancer
Baek, Sung Hee (South Korea)
16:00h - 16:25h
Epigenetic Regulation of Therapy Response in Cancers
Bagci-Onder, Tugba (Türkiye)
16:25h - 16:50h
Balancing X-Chromosome Dosage in Hematopoietic Cells: Mechanistic Insights and Impact on Cancer
YILDIRIM, Eda (Türkiye)
17:15h - 17:30h
BRPF1 links ribosome biogenesis and ABCB1 expression in chemoresistant triple-negative breast cancer cells
Yedier-Bayram, Ozlem (Türkiye)
17:30h - 17:45h
Deciphering the epigenetic code of genome stability, from soma to germline
Wang, Siyao (Germany)
17:45h - 17:48h
Special Sessions
Hall 2
6.7.2025
16:00 – 18:00h
FEBS & EFLM Joint Session – From bench to bedside and back: bridging biochemistry and clinical laboratory medicine
Chairs: Muhittin Serdar (TR) Tomas Zima (CZ)
Research vs. Clinical Laboratory Methods and Regulations: Understanding the Key Differences
Zima, Tomas (Czech Republic)
16:00h - 16:30h
Special Sessions
Hall 2
6.7.2025
16:00 – 18:00h
FEBS & EFLM Joint Session – From bench to bedside and back: bridging biochemistry and clinical laboratory medicine
Chairs: Muhittin Serdar (TR) Tomas Zima (CZ)
Beyond Counting: The Art and Science of Sample Size Determination in Life Sciences
Ceran Serdar, Ceyhan (Türkiye)
16:30h - 17:00h
Special Sessions
Hall 2
6.7.2025
16:00 – 18:00h
FEBS & EFLM Joint Session – From bench to bedside and back: bridging biochemistry and clinical laboratory medicine
Chairs: Muhittin Serdar (TR) Tomas Zima (CZ)
Metabolomics: A challenging journey from basic science to daily practice—reality or fairy tale?
Fux, Elie (Germany)
17:00h - 17:30h
Special Sessions
Hall 2
6.7.2025
16:00 – 18:00h
FEBS & EFLM Joint Session – From bench to bedside and back: bridging biochemistry and clinical laboratory medicine
Chairs: Muhittin Serdar (TR) Tomas Zima (CZ)
NGS:transforming public health from basic science to practical applications in oncology, cardiology, and predictive medicine
Ferrari, Maurizio (Italy)
17:30h - 18:00h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
Multi-protein assemblies orchestrate co-translational protein processing and folding on the human ribosome
Sinning, Irmgard (Germany)
09:00h - 09:25h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
Hidden Language of Proteins: Deciphering Allosteric Pathways with Gaussian Network Model
Haliloglu, Turkan (Türkiye)
09:25h - 09:50h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
Apicomplexan mitoribosome from highly fragmented rRNAs to a functional machine
Hashem, Yaser (Germany)
09:50h - 10:15h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
Understanding the regulation of ribosome assembly
Demo, Gabriel (Czech Republic)
10:15h - 10:30h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
Formylglycine and an alternative maturation system regulate nematode sulfatases
Sharma, Radhika (Germany)
10:30h - 10:45h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
Sequences of C-termini optimize the insertion of membrane proteins.
Kalinin, Ilya (Israel)
10:45h - 11:00h
Adaptation of cancer cells to hypoxia and acidosis in tumor microenvironment
Pastorekova, Silvia (Slovakia)
09:00h - 09:25h
Liquid biopsy: From discovery to clinical implementation
Pantel, Klaus (Germany)
09:25h - 09:50h
Cancer causing pathogens, cell plasticity and upper GI cancers
Lu, Xin (United Kingdom)
09:50h - 10:15h
Uncovering new vulnerabilities of ovarian cancer pharmacoresistance via unbiased identification of RNA-binding proteins
Avolio, Rosario (Italy)
10:15h - 10:30h
Polyphenolic cocktail (PFK5120) treatment of breast cancer cell lines: Superior anti-carcinogenic and anti-metastatic effects to doxorubicin
Ozkara, Gulcin (Türkiye)
10:30h - 10:45h
Development of EGFRvIII-Targeted Virus-Like Particles: Utilizing Diverse Cargo Proteins for Glioblastoma Cell Elimination
Bayraktar Odabas, Canan (Türkiye)
10:45h - 10:48h
Acylcarnitines in health and disease
Dambrova, Maija (Latvia)
09:00h - 09:25h
Cystic Fibrosis: A Paradigmatic Disease in Bringing Science to the Bedside
Amaral, Margarida (Portugal)
09:25h - 09:50h
SUMOylation in health and disease and its potential for targeted therapies
Sahin, Umut (Türkiye)
09:50h - 10:15h
Matricellular proteins THBS4 and OLFM – novel regulators of cutaneous wound healing.
Jaks, Viljar (Estonia)
10:15h - 10:30h
Coenzyme A biology, but not as we know it
Gout, Ivan (United Kingdom)
10:30h - 10:45h
Formyl-peptide receptor 2 stimulation enhances LAT1 expression and activates NOX-dependent mTORC1 signaling
Cassese, Myrhiam (Italy)
10:45h - 11:00h
Mechanisms of food allergy and the role of allergen-specific B cells
Akdis, Mubeccel (Switzerland)
11:30h - 12:30h
Lysosomal signaling in metabolic adaptation and tumorigenesis
Ballabio, Andrea (Italy)
14:30h - 15:30h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
Dynamics and synchronicity in catalytic mechanisms of homodimeric flavoenzymes
Medina, Milagros (Spain)
16:00h - 16:25h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
A Unified Mechanism for Lipid-Modified Protein Concentration in Primary Cilia and Immune Synapses
Ismail, Shehab (Belgium)
16:25h - 16:50h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
The biology of the centrosome/cilium complex in health and in disease
Firat Karalar, Elif Nur (Türkiye)
16:50h - 17:15h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
Solution structure of EMAP II cytokine reveals high conformational flexibility of dual function NPKKK motif involved both in RNA binding and nuclear export
Kornelyuk, Oleksandr (Ukraine)
17:15h - 17:30h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration
Gautreau, Alexis (France)
17:30h - 17:45h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
The Investigation of Molecular Function and Dynamics of CLIC4 During Cell Division
Değirmenci Alper, Beste Senem (Türkiye)
17:45h - 18:00h
Sleep well: the regulation of neural stem cell quiescence
Fariñas, Isabel (Spain)
16:00h - 16:25h
The microglial niche in neurodegeneration - understanding pathology and targeting for immunotherapy
Harris, Robert (Sweden)
16:25h - 16:50h
Regulation of neuronal stem cell activity during tissue maintenance and regeneration of the zebrafish olfactory epithelium.
Fuss, Stefan (Türkiye)
16:50h - 17:15h
Mapping the rules of glioblastoma using single cell and spatial genomics
Bayraktar, Omer (United Kingdom)
17:15h - 17:30h
Altered dopamine system in retinal degeneration – an epiphenomenon or a disease modifier?
Leinonen, Henri (Finland)
17:30h - 17:45h
Developing a prion-on-a-chip model to recapitulate the microphysiological brain environment to assess blood-brain barrier function
Tanjia, Nafisa (Türkiye)
17:45h - 18:00h
Welcome and introduction
Ucal, Yasemin (Germany)
16:00h - 16:10h
Democratizing access to biological & biomedical imaging technologies and image data services
Huerta, Daniela Aviles (Finland)
16:10h - 16:20h
DNA Binding Alters Androgen Receptor Variant Dimerization
Lack, Nathan (Canada)
16:20h - 16:30h
INFRAFRONTIER: Cutting-Edge Human Disease Modelling
Raess, Michael (Germany)
16:30h - 16:40h
Pioneering intranasal siRNA-based Nanovaccine
Florindo, Helena (Portugal)
16:40h - 16:50h
EU-OPENSCREEN – A collaborative initiative to accelerate early drug discovery
Stechmann, Bahne (Germany)
16:50h - 17:00h
Investigating the Mechanism of Action of Newly Discovered Anti-Prion Compounds via Chemoproteomics
Biasini, Emiliano (Italy)
17:00h - 17:10h
Instruct-ERIC – Access to latest Structural Biology technologies and training in Europe
Amaro, Claudia Alén (UK)
17:10h - 17:20h
The Mechanism of Lipid-targeting Antibiotics
Weingarth, Markus (Netherlands)
17:20h - 17:30h
Conclusion
Ucal, Yasemin (Germany)
17:50h - 18:00h
Symposia
Anadolu Auditorium
8.7.2025
09:00 – 11:00h
Protein life cycle III: Degradation: proteases, proteasome, autophagy
Chairs: Serkan Bolat (TR) Devrim Gözüaçık (TR)
Autophagy and cancer
Gozuacik, Devrim (Türkiye)
09:00h - 09:25h
Symposia
Anadolu Auditorium
8.7.2025
09:00 – 11:00h
Protein life cycle III: Degradation: proteases, proteasome, autophagy
Chairs: Serkan Bolat (TR) Devrim Gözüaçık (TR)
Lysosome integrity - a matter of life and death
Stenmark, Harald (Norway)
09:25h - 09:50h
Symposia
Anadolu Auditorium
8.7.2025
09:00 – 11:00h
Protein life cycle III: Degradation: proteases, proteasome, autophagy
Chairs: Serkan Bolat (TR) Devrim Gözüaçık (TR)
The role of peptidases in shaping the fate of immune cells in tumor microenvironment
Kos, Janko (Slovenia)
09:50h - 10:15h
Symposia
Anadolu Auditorium
8.7.2025
09:00 – 11:00h
Protein life cycle III: Degradation: proteases, proteasome, autophagy
Chairs: Serkan Bolat (TR) Devrim Gözüaçık (TR)
Molecular dynamics study of ATG13 ubiquitylation in ULK1 structural dynamics and assembly of the autophagy initiation complex
Catalanotti, Bruno (Italy)
10:15h - 10:30h
Symposia
Anadolu Auditorium
8.7.2025
09:00 – 11:00h
Protein life cycle III: Degradation: proteases, proteasome, autophagy
Chairs: Serkan Bolat (TR) Devrim Gözüaçık (TR)
Structures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism of ubiquitin-independent proteasomal degradation
Cuéllar, Jorge (Spain)
10:30h - 10:45h
Symposia
Anadolu Auditorium
8.7.2025
09:00 – 11:00h
Protein life cycle III: Degradation: proteases, proteasome, autophagy
Chairs: Serkan Bolat (TR) Devrim Gözüaçık (TR)
Molecular mechanism and efficacy of 4',5,7-trihydroxyisoflavone in correction of symptoms of Huntington disease as revealed by studies with cellular and animal models
Wegrzyn, Grzegorz (Poland)
10:45h - 10:48h
Rapid but reliable: The evolution of viral diagnostic assays with TR-FRET
Hepojoki, Jussi (Finland)
09:00h - 09:25h
Revolutionizing Sepsis Care: The Role of Circulating Histones as Clinical Biomarkers
García Giménez, Jose Luis (Spain)
09:25h - 09:50h
Multi-omics biomarker approaches in precision medicine
van Gool, Alain J. (Netherlands)
09:50h - 10:15h
Aquaporin 8 upregulation is associated with hepatic inflammation and oxidative stress in ketogenic diet fed ApoE knock-out mice
da Silva, Inês V. (Portugal)
10:15h - 10:30h
Evaluation of the relationship between serum and pleural fluid lipid raft protein levels with plasma inflammatory biomarkers
Demirtas, Oznur (Türkiye)
10:30h - 10:45h
Unveiling the potential therapeutic role of Salvia dorystoechas extract in combating type-3 diabetes-linked neurodegeneration
Aksu, Sevil (Türkiye)
10:45h - 10:48h
Nature-based Engineering of Photosynthetic light harvesting systems
Bassi, Roberto (Italy)
09:00h - 09:25h
Halophiles & the saline world: Are fructans the key to survive?
Toksoy Öner, Ebru (Türkiye)
09:25h - 09:50h
You’ll never walk alone: combining enzymatic and physical treatments to improve quality and sustainability in food systems
Iametti, Stefania (Italy)
09:50h - 10:15h
Exploring Next-Generation Sequencing Technologies for the Discovery of Extremozymes from Tunisia’s Extreme Biotopes for Application in Sustainable Industrial Processes
Jaouadi, Bassem (Tunisia)
10:15h - 10:30h
Heterologous expression of a novel laccase (YeLac) from Yersinia enterocolitica with enhanced dye decolorization and tetracycline degradation potential
ÖZDEMİR, F. İnci (Türkiye)
10:30h - 10:45h
Identification of strong promoters from Saccharomyces species for gene expression in budding yeast Saccharomyces cerevisiae
Franic, Dina (Croatia)
10:45h - 10:48h
Understanding antioxidants in health and disease: the special case of ergothioneine
Halliwell, Barry (Singapore)
11:30h - 12:30h
Yin and Yang does not need to be a choice in academia – how research and education are linked and mutually compatible
Harris, Robert (Sweden)
14:30h - 15:30h
Symposia
Anadolu Auditorium
8.7.2025
16:00 – 18:00h
AI – application in basic and applied biomolecular sciences
Chairs: Oguzhan Zengi (TR) Atakan Ekiz (TR)
Combining simple biophysical models with deep learning for the improved characterization of intrinsically disordered proteins
Dosztányi, Zsuzsanna (Hungary)
16:00h - 16:25h
Symposia
Anadolu Auditorium
8.7.2025
16:00 – 18:00h
AI – application in basic and applied biomolecular sciences
Chairs: Oguzhan Zengi (TR) Atakan Ekiz (TR)
Exploring breast cancer immune microenvironment through an interactive analysis platform
Ekiz, H. Atakan (Türkiye)
16:25h - 16:50h
Symposia
Anadolu Auditorium
8.7.2025
16:00 – 18:00h
AI – application in basic and applied biomolecular sciences
Chairs: Oguzhan Zengi (TR) Atakan Ekiz (TR)
AI revolution in the structure prediction of biomolecular complexes
Karaca, Ezgi (Türkiye)
16:50h - 17:15h
Symposia
Anadolu Auditorium
8.7.2025
16:00 – 18:00h
AI – application in basic and applied biomolecular sciences
Chairs: Oguzhan Zengi (TR) Atakan Ekiz (TR)
Multi-View Machine Learning for Massively Multiplexed Biological Fluorescence Imaging
Valm, Alex (United States of America)
17:15h - 17:30h
Symposia
Anadolu Auditorium
8.7.2025
16:00 – 18:00h
AI – application in basic and applied biomolecular sciences
Chairs: Oguzhan Zengi (TR) Atakan Ekiz (TR)
Predictive models of iPSC differentiation enable efficient tissue-specific differentiation and better control of cell fate
Post, Janine (Netherlands)
17:30h - 17:45h
Symposia
Anadolu Auditorium
8.7.2025
16:00 – 18:00h
AI – application in basic and applied biomolecular sciences
Chairs: Oguzhan Zengi (TR) Atakan Ekiz (TR)
Simple Protein Multimeric State Reconstruction Using Input Filtering with AlphaFold2
Sulea, Teodor Asvadur (Romania)
17:45h - 17:48h
Cell proliferation and chromatin dynamics during organ growth
Gutierrez, Crisanto (Spain)
16:00h - 16:25h
Aminoacyl-tRNA synthetases: catalysis and antibiotic (hyper)resistance
Gruić Sovulj, Ita (Croatia)
16:25h - 16:50h
Chromosomal R-loops: who R they?
Szekvolgyi, Lorant (Hungary)
16:50h - 17:15h
A novel piRNA annotation tool (piRAT) unveils new piRNA expression patterns
Ylla, Guillem (Poland)
17:15h - 17:30h
Genomic-Transcriptomic Differences in Peripheral Blood of Healthy Aging: Insights for Neurodegenerative Disease
Tepgeç, Fatih (Türkiye)
17:30h - 17:45h
Novel kinetoplast genome structure and RNA editing patterns in the trypanosomatid Vickermania
Yurchenko, Vyacheslav (Czech Republic)
17:45h - 18:00h
From Wnt to Wisdom: Tackling Alzheimer’s Disease
Ozhan, Gunes (Türkiye)
09:00h - 09:25h
Special Sessions
Hall 1
9.7.2025
09:00 – 11:00h
FEBS Press Session
FEBS Press interactive session on scientific publishing
FEBS Press Editors
09:00h - 10:00h
Epithelial Barrier Theory and Molecular Mechanisms of Tissue Injury in Allegic and Autoimmune Diseases
Akdis, Cezmi (Switzerland)
09:00h - 09:25h
Resolving how vaccine adjuvants promote T cell responses
Lavelle, Ed (Ireland)
09:25h - 09:50h
Molecular insights into the immune mechanism of bacterial antiviral defense system Thoeris
Tamulaitiene, Giedre (Lithuania)
09:50h - 10:15h
The bitter taste receptor (TAS2R) agonist amarogentin enhances mucociliary clearance and reduces airway inflammation in ovalbumine-induced guinea pig asthma
Mažerik, Jozef (Slovakia)
10:15h - 10:30h
S1PR1 Modulation Mitigates LPS-Induced Testicular Inflammation by Restoring Antioxidant Defenses and Suppressing Proinflammatory Cytokines
Yigit, Ertugrul (Türkiye)
10:30h - 10:45h
Epigenetics meets oxidative stress to provide novel biomarkers for sepsis diagnosis, stratification, and prognosis
Cánovas-Cervera, Irene (Spain)
10:45h - 10:48h
SKDEAS intellectual disability syndrome: Pathogenic mechanism revealed by an impaired E3 ubiquitin ligase
Alpi, Arno (United Kingdom)
11:30h - 12:00h
Cholesterol-mediated ERRα activation in breast cancer progression and microenvironment
Brindisi, Matteo (Italy)
12:00h - 12:30h
RNA mechanisms associated with C9orf72 mutation
Rogelj, Boris (Slovenia)
13:30h - 13:55h
The 3’-end of the tale
Erson Bensan, Ayse Elif (Türkiye)
13:55h - 14:20h
Molecular and genetic analysis of cytoplasmic RNA-binding proteins in infertility
Gray, Nicola (United Kingdom)
14:20h - 14:45h
RBFOX2-REGULATED RNA NETWORKS NECESSARY FOR EARLY CARDIOVASCULAR DEVELOPMENT
Kuyumcu-Martinez, Muge (United States of America)
14:45h - 15:00h
Investigation of a squaramide motif as a bioisostere of the amino-acid group of S- adenosyl-L-methionine and its functional impact on RNA methylation.
MAHCENE, Batoul (France)
15:00h - 15:15h
Special Sessions
Hall 1
9.7.2025
13:30 – 15:30h
FEBS & ORPHEUS Joint Session - PhD training in a changing world: Standards, ethics, and career growth
Chairs: Gül Güner Akdogan (TR) John Creemers (BE)
Unlocking Your Research Potential: How Mentorship, Leadership, and Support Can Shape a Bright Career Path.
Arraiano, Cecilia (Portugal)
15:00h - 15:30h
Special Sessions
Hall 1
9.7.2025
13:30 – 15:30h
FEBS & ORPHEUS Joint Session - PhD training in a changing world: Standards, ethics, and career growth
Chairs: Gül Güner Akdogan (TR) John Creemers (BE)
How Doctoral Schools can Engage in a Common Direction for Research Assessment Reform, While Maintaining Organizations’ Autonomy-ORPHEUS Perspective
creemers, john (Belgium)
13:30h - 14:00h
Special Sessions
Hall 1
9.7.2025
13:30 – 15:30h
FEBS & ORPHEUS Joint Session - PhD training in a changing world: Standards, ethics, and career growth
Chairs: Gül Güner Akdogan (TR) John Creemers (BE)
ORPHEUS labelling: A thrive for perfection in PhD training
Güner Akdoğan, Gül (Türkiye)
14:00h - 14:30h
Special Sessions
Hall 1
9.7.2025
13:30 – 15:30h
FEBS & ORPHEUS Joint Session - PhD training in a changing world: Standards, ethics, and career growth
Chairs: Gül Güner Akdogan (TR) John Creemers (BE)
Generalized Bioethics Training in PhD Education: A Necessity Beyond Health Sciences?
Orer, Sedat Hakan (Türkiye)
14:30h - 15:00h
Thinking differently about cancer treatment regimens
Bernards, Rene (Netherlands)
16:00h - 16:30h
Corruption of host immune defenses by bacterial proteases in chronic inflammatory diseases
Potempa, Jan (United States of America)
16:30h - 17:00h
Plenary Lectures
Anadolu Auditorium
9.7.2025
17:00 – 18:00h
IUBMB Jubilee Award Lecture – Closing Plenary Lecture
Chairs: Alain Krol (FR) Loredano Pollegoni (IT)
Boosting cellular defense mechanisms as a treatment for neurodegenerative diseases: From the bench to the clinic.
Bertolotti, Anne (United Kingdom)
17:00h - 18:00h
Special Sessions
Hall 1
9.7.2025
09:00 – 11:00h
FEBS Press Session
How to create an effective graphical abstract
Oliverio, Matteo (Germany)
10:00h - 11:00h
Leveraging artificial intelligence in biomedical and biological data analysis: Challenges and opportunities
SWIDERSKA-CHADAJ, Zaneta (Poland)
09:25h - 09:50h
Hydrocolloid-based bioplastics as biocompatible and sustainable composite materials
Mariniello, Loredana (Italy)
09:50h - 10:15h
Tyrosine kinase inhibitor induces changes in the 3D genome organization of lung cancer cells leading to expression of tumor suppressor genes
Barreto, Guillermo (France)
16:50h - 17:15h
Symposia
Anadolu Auditorium
6.7.2025
09:00 – 11:00h
Structural biology: from complexes to membrane-less organelles
Chairs: Umut Sahin (TR) Edward A. Lemke (DE)
The disease-linked R336C mutation in Cystathionine β-synthase disrupts communication with the PLP cofactor yet maintains the enzyme's overall structural integrity
Conter, Carolina (Spain)
10:48h - 10:51h
Symposia
Anadolu Auditorium
6.7.2025
09:00 – 11:00h
Structural biology: from complexes to membrane-less organelles
Chairs: Umut Sahin (TR) Edward A. Lemke (DE)
Structural and biochemical characterization of novel Heme Oxygenase 1 (HO-1) inhibitors
Butticè, Andrea (Italy)
10:51h - 10:54h
Symposia
Anadolu Auditorium
6.7.2025
09:00 – 11:00h
Structural biology: from complexes to membrane-less organelles
Chairs: Umut Sahin (TR) Edward A. Lemke (DE)
Ancestral ThiD-HMPPK enzyme reveals essential residues for HMP-P phosphorylation through X-ray crystallography and molecular dynamics simulation.
Castro-Fernandez, Victor (Chile)
10:54h - 10:57h
Symposia
Hall 1
6.7.2025
09:00 – 11:00h
FEBS & Cell Death Research Society Joint Session – Cell stress, cell senescence, and cell death decisions
Chairs: H. Seda Vatansever (TR) Peter Vandenabeele (BE)
Increased catalytic activity of C3G suppresses B cell lymphoma growth and survival, while enhancing migration and invasion
Morán Vaquero, Alba (Spain)
10:48h - 10:51h
Symposia
Hall 1
6.7.2025
09:00 – 11:00h
FEBS & Cell Death Research Society Joint Session – Cell stress, cell senescence, and cell death decisions
Chairs: H. Seda Vatansever (TR) Peter Vandenabeele (BE)
Exploring the role of Bcl-2 family proteins in regulating entry to DNA damage-induced replicative senescence
Gallagher Aldave, Aislinn (Ireland)
10:51h - 10:54h
Symposia
Hall 1
6.7.2025
09:00 – 11:00h
FEBS & Cell Death Research Society Joint Session – Cell stress, cell senescence, and cell death decisions
Chairs: H. Seda Vatansever (TR) Peter Vandenabeele (BE)
Integrating proteomics, systems biology and drug-repurposing to identify therapeutic targets in lymphoid neoplasms
Psatha, Konstantina (Greece)
10:54h - 10:57h
Ergosterol and Its Metabolites as Liver X Receptor Agonists: Exploring Their Anticancer Potential in Colorectal Cancer Through Experimental Models and Molecular Mechanisms.
Agnihotri, Navneet (India)
10:48h - 10:51h
Altered bone marrow adipose tissue secretory profile induced by aryl hydrocarbon receptor inhibition can modulate the leukemic microenvironment
Muratoğlu, Bihter (Türkiye)
10:51h - 10:54h
Breast cancer extracellular vesicles modulate the unfolded protein response in macrophages
Nagy, Ferenc István (Hungary)
10:54h - 10:57h
Synergistic Effects of HDAC Inhibitor Quisinostat and 5-Fluorouracil on Colorectal Cancer Cellular Processes
Calibasi-Kocal, Gizem (Türkiye)
17:48h - 17:51h
Therapeutic Modulation of lncRNA Expression in Thyroid Cancer: A Gene Expression Study
Albulescu, Adrian (Romania)
17:51h - 17:54h
Transforming Molecular Teaching in the Metaverse
Martínez-Sánchez, Sara Mª (Spain)
17:54h - 17:57h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
Synthesis and catabolism of modified heterocyclic bases
Ivaškė, Augusta (Lithuania)
11:00h - 11:03h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
Serum glycan profiling towards aberrant glycosylation in bone cancers
Muhamad, Mudiana (Malaysia)
11:03h - 11:06h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
The role of CUE5 on protein aggregation under heat shock stress in S. cerevisiae
Kocabas, Dilge (Türkiye)
11:06h - 11:09h
Symposia
Anadolu Auditorium
7.7.2025
09:00 – 11:00h
Protein life cycle I: Dynamics of protein synthesis and folding
Chairs: Suat Erdogan (TR) Türkan Haliloğlu (TR)
Better Together? Student and Academic Staff perceptions to inform effective team-based assessments
Rutherford, Stephen (United Kingdom)
11:09h - 11:12h
Phenotype-specific cancer targeting: mesenchymal stem cells as therapeutic nanocomplex carriers
Daugelaite, Aleja Marija (Lithuania)
10:48h - 10:51h
The oncomucin MUC4 EGF domains: A new paradigm to target ErbB/HER and RTK receptors in pancreatic adenocarcinoma using inhibitory small molecules
VAN SEUNINGEN, Isabelle (France)
10:51h - 10:54h
Dual role of tumor associated macrophages in acquired resistance to second-generation androgen receptor antagonists in hormone sensitive prostate cancer cells
HUNC, Fatih (Türkiye)
10:54h - 10:57h
The first report of MEI4 biallelic variant in primary infertility: A familial case study
Agirbasli, Deniz (Türkiye)
11:00h - 11:03h
Circulating extracellular vesicles as biomarkers of endothelial injury in idiopathic pulmonary fibrosis
Agafonova, Aleksandra (Italy)
11:03h - 11:06h
CRISPR-Cas9-based deletion of glutathione synthetase in Leishmania donovani demonstrates its essential role in growth and virulence
Sarma, Manash (India)
11:06h - 11:09h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
CacyBP/SIP - RPL6 interaction: potential influence on ribosome function
Saberi Khomami, Omid (Poland)
18:00h - 18:03h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
Elevated CHK1 expression in hepatic stellate cells offers an adaptive mechanism against replication stress
Lee, Eui Jin (South Korea)
18:03h - 18:06h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
Differential functions of HSPA1 and HSPA2 chaperones in human epithelial cells
Wiecha, Klaudia (Poland)
18:06h - 18:09h
Symposia
Anadolu Auditorium
7.7.2025
16:00 – 18:00h
Protein life cycle II: Protein localization and dynamics
Chairs: Kemal Baysal (TR) Elif Nur Fırat Karalar (TR)
PDGF-DD and Imatinib Shape MSC Anti-Fibrotic Behavior Through PDGFR-β Modulation
Keleş, Mustafa (Türkiye)
18:09h - 18:12h
Intrathecal administration of AAVrh10-mHexa alleviates neuropathological manifestations in a mouse model of Tay-Sachs disease
Can Özgür, Melike (Türkiye)
18:00h - 18:03h
Identifying Small Molecules in Multiple Sclerosis via NMR Spectroscopy
Sengul, Pinar (Türkiye)
18:03h - 18:06h
Single-domain antibodies targeting S100B chaperone amplify its anti-aggregation activity and inhibit Tau aggregation in Alzheimer's disease
Simões, Margarida C. (Portugal)
18:06h - 18:09h
Boron-Supplemented Fecal Microbiota Transplantation Exhibits Therapeutic Effects on the Gut-Brain-Microbiota Axis in NCM460 Cell Injury and Neuroinflammation Rat Model
Kar, Fatih (Türkiye)
18:09h - 18:12h
Symposia
Anadolu Auditorium
8.7.2025
09:00 – 11:00h
Protein life cycle III: Degradation: proteases, proteasome, autophagy
Chairs: Serkan Bolat (TR) Devrim Gözüaçık (TR)
Effects Of A Polyphenolic Chemical Mixture On The Apoptotis Pathway Of A Triple Negative Breast Cancer Cell Line
Eronat, Allison Pınar (Türkiye)
10:48h - 10:51h
Symposia
Anadolu Auditorium
8.7.2025
09:00 – 11:00h
Protein life cycle III: Degradation: proteases, proteasome, autophagy
Chairs: Serkan Bolat (TR) Devrim Gözüaçık (TR)
PROTEOMIC STUDY OF BACTERIAL ENZYMES AT THE HOST–PATHOGEN INTERFACE IN LEGIONELLOSIS
Dubois, Oceane (France)
10:51h - 10:54h
Symposia
Anadolu Auditorium
8.7.2025
09:00 – 11:00h
Protein life cycle III: Degradation: proteases, proteasome, autophagy
Chairs: Serkan Bolat (TR) Devrim Gözüaçık (TR)
Interactive Learning in Molecular Life Sciences: Enhancing Molecular Visualization with Authentic Data Resources, Molecular Case Studies, and Augmented Reality
Vardar-Ulu, Didem (United States of America)
10:54h - 10:57h
Enhanced glutaminolysis promotes hepatic iron accumulation and aging through lysosomal dysfunction
Goikoetxea-Usandizaga, Naroa (Spain)
10:48h - 10:51h
TSC22D1 interacts with FoxO1 to regulate beta cell function
Yıldırım, Sümbül (Türkiye)
10:51h - 10:54h
Ciliary dysfunction compromises mitochondrial homeostasis
Solarat, Carlos (Spain)
10:54h - 10:57h
Evolutionary Engineering and Molecular Characterization of an Antimycin A-Resistant Saccharomyces cerevisiae Strain
Topaloğlu, Alican (Türkiye)
10:48h - 10:51h
Multiscale in silico modeling and simulation of an antibody at ultra-low temperatures: impact of cryoprotectants and insights into the dimerization phenomenon.
Ravy, LEON FOUN LIN (France)
10:51h - 10:54h
Exploring molecular adaptations of tRNA recognition in bacterial isoleucyl-tRNA synthetase type 2
Kozulić, Petra (Croatia)
10:54h - 10:57h
Symposia
Anadolu Auditorium
8.7.2025
16:00 – 18:00h
AI – application in basic and applied biomolecular sciences
Chairs: Oguzhan Zengi (TR) Atakan Ekiz (TR)
Protein Predictive Modeling and Dynamic Simulation for ALK/GSK-3 Mutation and Therapeutic Targeting in Neuroblastoma
Lutimba, Stuart (United Kingdom)
17:48h - 17:51h
Symposia
Anadolu Auditorium
8.7.2025
16:00 – 18:00h
AI – application in basic and applied biomolecular sciences
Chairs: Oguzhan Zengi (TR) Atakan Ekiz (TR)
Assessing the relation between protein phosphorylation, AlphaFold3 models and conformational variability
Ramasamy, Pathmanaban (Belgium)
17:51h - 17:54h
Symposia
Anadolu Auditorium
8.7.2025
16:00 – 18:00h
AI – application in basic and applied biomolecular sciences
Chairs: Oguzhan Zengi (TR) Atakan Ekiz (TR)
Investigating Genetic Diversity and Toxin Production through Systems-Level Metabolic Modelling of Clostridium botulinum
Islam, M. Ahsanul (United Kingdom)
17:54h - 17:57h
Transcriptomic Analysis Reveals Mast Cell Activity Enhances Ferroptosis in Fibroblasts in Gastric Cancer
Sert, Fatma (Türkiye)
18:00h - 18:03h
ACRC (GCNA) is a conserved DNA-protein crosslink repair protease that cleaves multiple substrates during vertebrate development
Kutnjak, Marin (Croatia)
18:03h - 18:06h
In-depth miRNA profiling uncovers unique microRNA signatures in the neuroglia of the Tay-Sachs disease mouse model
Kaya, Beyza (Türkiye)
18:06h - 18:09h
A study of putative transcription factors in Bacillus subtilis reveals a novel mechanism of resistance to the antibiotic D-cycloserine
Kočárková, Veronika (Czech Republic)
18:09h - 18:12h
KDM4 inhibitor design for cancer therapy: a structure-based approach
Małecki, Piotr (Poland)
10:15h - 10:30h
Evaluation of freeze-dried Daratumumab immunoconjugate kits for Lutetium-177 radiolabeling
Apostolova, Paulina (Macedonia (FYROM))
10:30h - 10:45h
Repurposing clinically approved drugs as promising inhibitors of matrix metalloproteinase-2
Tuncal, Akıle (Cyprus)
10:45h - 10:48h
PDIA3: A Novel Target for the Development of Broad-Spectrum Antiviral and Anticancer Agents
Testori, Fabio (Italy)
10:48h - 10:51h
Discovery And Functional Characterization Of Novel Fascin1 Inhibitor Drug Against Colorectal And Breast Carcinoma
Cruz, Andreia Filipa (Spain)
10:51h - 10:54h
Functional and structural study of viral responsive protein 15 (PmVRP15) from black tiger shrimp Penaeus monodon
Krusong, Kuakarun (Thailand)
10:54h - 10:57h
IL-17-producing γδ T cells played a pathogenic role in Sjögren’s syndrome
ZHAO, Mengna (Hong Kong)
10:48h - 10:51h
The pivotal role of the NKG2D receptor in the cytotoxic activity of NK cells towards fibroblast-like iPSC derivatives
Sherman, Daria (Russia)
10:51h - 10:54h
Platelet C3G modulates the immune response in a murine colitis model
Sicilia-Navarro, Carmen (Spain)
10:54h - 10:57h
Dual role of a single residue in isoleucyl-tRNA synthetase: ensuring specificity of the synthetic site and maintaining its communication with the editing site
Dulic, Morana (Croatia)
15:15h - 15:18h
Site-directed RNA editing systems: a particular endogenous target
Patricelli, Eliana (Germany)
15:18h - 15:21h
Deficiency of B4Galnt1 rescues the neuroinflammatory and neurodegenerative courses of Tay-Sachs disease mouse model
Yanbul, Selman (Türkiye)
11:09h - 11:12h
Identification of Apoptosis-Related Circular RNAs in Hematological Malignancies by Coupling Nanopore Sequencing with Next-Generation Sequencing
Sotiropoulou, Christina D (Greece)
15:24h - 15:27h
GM1 oligosaccharide as a therapeutic candidate for neurodegenerative diseases, targeting mitochondrial dysfunction and protein dysregulation: a focus on Amyotrophic Lateral Sclerosis
Lunghi, Giulia (Italy)
18:12h - 18:15h
Luteolin attenuates MPP+-induced neurodegeneration via modulation of oxidative stress, apoptosis, and PRDX-6 expression
AKBULUT, Derya (Türkiye)
15:21h - 15:24h